Nobuo Nagano Selected Research

Sevelamer (RenaGel)

3/2006	Sevelamer hydrochloride reverses parathyroid gland enlargement via regression of cell hypertrophy but not apoptosis in rats with chronic renal insufficiency.
9/2005	[Effects of intermittent treatment with sevelamer hydrochloride on parathyroid hyperplasia and vascular calcification in rats with chronic kidney disease].
6/2004	[Sevelamer hydrochloride prevents ectopic calcification of blood vessels].
11/2003	[Pharmacological and clinical trial data on a novel phosphate-binding polymer (sevelamer hydrochloride), a medicine for hyperphosphatemia in hemodialysis patients].
10/2003	Sevelamer hydrochloride, a phosphate binder, protects against deterioration of renal function in rats with progressive chronic renal insufficiency.
8/2003	Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats.
6/2003	Sevelamer hydrochloride, a calcium-free phosphate binder, inhibits parathyroid cell proliferation in partially nephrectomized rats.

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Nobuo Nagano Research Topics

Disease

15	Chronic Renal Insufficiency 01/2018 - 05/2000
14	Secondary Hyperparathyroidism 06/2012 - 05/2000
8	Hyperplasia 07/2011 - 05/2000
5	Vascular Calcification 01/2015 - 11/2003
4	Hyperphosphatemia 12/2018 - 11/2003
4	Renal Insufficiency (Renal Failure) 01/2018 - 08/2003
4	Hyperparathyroidism 07/2011 - 11/2003
4	Primary Hyperparathyroidism 07/2011 - 10/2005
3	Chronic Kidney Failure (Chronic Renal Failure) 03/2006 - 08/2003
2	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 01/2015 - 08/2003
2	Uremia 11/2008 - 01/2006
2	Fibrosis (Cirrhosis) 01/2006 - 08/2003
2	Hypercalcemia (Milk Alkali Syndrome) 10/2005 - 11/2003
1	Constipation 01/2015
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2006
1	Hypertrophy 03/2006
1	Neoplasms (Cancer) 01/2006
1	Anemia 01/2006
1	Body Weight (Weight, Body) 10/2005
1	Hypoparathyroidism 11/2003

Drug/Important Bio-Agent (IBA)

11	Cinacalcet (Sensipar)FDA Link 10/2012 - 06/2003
10	Phosphates (Orthophosphate)IBA 12/2018 - 05/2000
10	CalciumIBA 11/2010 - 05/2000
9	Parathyroid Hormone (Parathormone)IBA 10/2012 - 05/2000
8	Phosphorus (Red Phosphorus)IBA 03/2006 - 06/2003
7	Sevelamer (RenaGel)FDA Link 03/2006 - 06/2003
6	Fibroblast Growth Factor-23IBA 01/2018 - 09/2005
3	Proteins (Proteins, Gene)FDA Link 01/2015 - 03/2005
3	Pharmaceutical PreparationsIBA 10/2012 - 03/2005
3	N- (2- chlorophenylpropyl)- 1- (3- methoxyphenyl)ethylamineIBA 03/2006 - 05/2000
3	Adenine FDA LinkGeneric 09/2005 - 08/2003
2	Cyclin D1IBA 07/2011 - 10/2005
2	Hormones (Hormone)IBA 07/2011 - 09/2005
2	Vitamin D FDA LinkGeneric 11/2010 - 11/2003
2	1,25-dihydroxyvitamin DIBA 11/2010 - 06/2003
2	Calcium-Sensing ReceptorsIBA 01/2006 - 10/2005
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018
1	polydextroseIBA 01/2015
1	MineralsIBA 01/2015
1	Lactose FDA LinkGeneric 11/2008
1	MetalsIBA 03/2006
1	Calcitriol (Calcijex)FDA LinkGeneric 03/2006
1	NitrogenIBA 01/2006
1	IronIBA 01/2006
1	Urea (Carbamide)FDA LinkGeneric 01/2006
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2006
1	CreatinineIBA 01/2006
1	Acetylglucosaminidase (NAGase)IBA 01/2006
1	PolymersIBA 11/2003

Therapy/Procedure

3	Nephrectomy 01/2018 - 05/2000
1	Oral Administration 03/2005
1	Renal Dialysis (Hemodialysis) 11/2003
1	Subcutaneous Infusions 05/2000